Browsing by Author "Sener, Azize"
Now showing items 1-9 of 9
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The apoptotic actions of platelets in acute ischemic stroke
Cevik, Ozge; Adiguzel, Zelal; Baykal, Ahmet Tarik; Somay, Goksel; Sener, Azize (SPRINGER, 2013)Stroke is a disease that affects the blood vessels that supply blood to the brain. Although platelets are implicated in the pathophysiology of stroke the mechanism is still not clear and there antiplatelet agents available ... -
Beneficial effects of quercetin on rat urinary bladder after spinal cord injury
Cevik, Ozge; Ersahim, Mehmet; Sener, T. Emre; Tinay, Ilker; Tarcan, Tufan; Cetinel, Sule; Sener, Azize; Toklu, Hale Z.; Sener, Goksel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)Background: Spinal cord injury (SCI) leads to an inflammatory response and generates oxidative stress, which has deleterious effects on the function of several organ systems, including the urinary bladder. The present study ... -
The effects of topical melatonin on oxidative stress, apoptosis signals, and p53 protein expression during cutaneous wound healing
Sener, Azize; Cevik, Ozge; Dogan, Ozge; Altindis, Nazli Gul; Aksoy, Halil; Okuyan, Betul (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2015)Elimination of reactive oxygen species (ROS) can be an important strategy to improve healing of wounds. ROS have an effect on proliferation and cell survival signaling, which results in alteration of apoptotic pathways in ... -
Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury
Ersahin, Mehmet; Cevik, Ozge; Akakin, Dilek; Sener, Azize; Ozbay, Latif; Yegen, Berrak C.; Sener, Goksel (ELSEVIER SCIENCE INC, 2012)Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Leukotrienes are biologically active 5-lipoxygenase products of arachidonic ... -
Platelets Proteomic Profiles of Acute Ischemic Stroke Patients
Cevik, Ozge; Baykal, Ahmet Tarik; Sener, Azize (PUBLIC LIBRARY SCIENCE, 2016)Platelets play a crucial role in the pathogenesis of stroke and antiplatelet agents exist for its treatment and prevention. Through the use of LC-MS based protein expression profiling, platelets from stroke patients were ... -
Synthesis and Characterization of Celecoxib Derivatives as Possible Anti-Inflammatory, Analgesic, Antioxidant, Anticancer and Anti-HCV Agents
Kucukguzel, S. Guniz; Coskun, Inci; Aydin, Sevil; Aktay, Goknur; Gursoy, Sule; Cevik, Ozge; Ozakpinar, Ozlem Bingol; Ozsavci, Derya; Sener, Azize; Kaushik-Basu, Neerja; Basu, Amartya; Talele, Tanaji T. (MDPI, 2013)A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamides 2a-e were synthesized by the addition of ethyl alpha-bromoacetate ... -
Synthesis of Diflunisal Thiazolidinones as Anticancer Agents
Senkardes, Sevil; Ozakpinar, Ozlem B.; Ozsavci, Derya; Sener, Azize; Cevik, Ozge; Kucukguzel, S. Guniz (BENTHAM SCIENCE PUBL LTD, 2016)A series of diflunisal 4-thiazolidinones were synthesized. Some selected compounds were determined at one dose towards the full panel of 60 human cancer cell lines by National Cancer Institute. 2',4'-Difluoro-4-hydroxy-N ... -
Synthesis, Cytotoxicity, and Pro-Apoptosis Activity of Etodolac Hydrazide Derivatives as Anticancer Agents
Cikla, Pelin; Ozsavci, Derya; Bingol-Ozakpinar, Ozlem; Sener, Azize; Cevik, Ozge; Ozbas-Turan, Suna; Akbuga, Julide; Sahin, Fikrettin; Kucukguzel, S. Guniz (WILEY-V C H VERLAG GMBH, 2013)Etodolac hydrazide and a novel series of etodolac hydrazide-hydrazones 315 and etodolac 4-thiazolidinones 1626 were synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, 1H NMR, ... -
Tumor necrosis factor-alpha induced caspase-3 activation-related iNOS gene expression in ADP-activated platelets
Cevik, Ozge; Adiguzel, Zelal; Baykal, Ahmet Tarik; Sener, Azize (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2017)Platelets are sensitive cells and are easily activated by different stimulants in the circulation system. It is known that tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine and plays a role in inflammation. ...